IVF supplements can improve egg quality and quantity; learn what vitamins and supplements to use for better IVF results
October 9, 2023
The quality and quantity of a woman's eggs are crucial in achieving a successful pregnancy. Multiple studies demonstrated that nutrition and, particularly, certain supplements may boost natural fertility. In this article, we will explore the world of egg quality supplements, discuss their benefits, whether there is any scientific proof justifying their use, and provide insights into how they can support fertility, especially for those undergoing in vitro fertilization (IVF) or dealing with low ovarian reserve.
Egg quality refers to the overall health and vitality of a woman's eggs. High-quality eggs are more likely to fertilize successfully, resulting in a healthy embryo and a successful pregnancy. Factors such as age, genetics, lifestyle, and environmental exposures can affect egg quality. As women age, the quality and quantity of their eggs naturally decline, making conception more challenging.
Coenzyme Q10 (CoQ10): CoQ10 is a powerful antioxidant that helps protect eggs from oxidative stress, a common factor contributing to poor egg quality. It may also enhance mitochondrial function, which is crucial for healthy egg development. While scientific evidence is still limited, the existing studies demonstrate an improved clinical pregnancy rate(28.8% to 14%) versus placebo in IVF cycles.
Myo-inositol: Myo-inositol has shown promise in improving egg quality and ovarian function for PCOS patients going through different infertility treatments. It works by reducing the level of male hormone (testosterone), correcting the LH/FSH ratio, and helping to normalize the menstrual cycle and induce ovulation. For the IVF cycle, it may mean lower FSH dosage and better maturation of eggs. Existing studies mostly evaluate the results of myo-inositol supplementation together with folic acid, and no large studies exist comparing myo-inositol to placebo. Largest recent study demonstrated that a combination of 4g/day of myo-inositol and 400 mg/day of folic acid seem to increase clinical live-birth and lower FSH dosage with ovulation induction for PCOS patients.
Omega-3 Fatty Acids: Omega-3 fatty acids can improve egg quality, according to a recent study of women going through assisted reproduction treatment or IVF, resulting in better live birth and clinical pregnancy.
DHEA (Dehydroepiandrosterone): DHEA is a hormone produced by adrenal glands that promotes the production of androgens and estrogens and peaks during the mid-20s and decreases over age. It is often recommended for women with poor ovarian response to stimulations due to age, prior poor response, and also abnormal ovarian reserve tests (such as low AMH and AFC). Its use has shown improved pregnancy rate. In analyzed studies, it was administered in 25 mg three times daily from 6 to 16 weeks before cycle.
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Vitamin D insufficiency was associated with miscarriage and pregnancy loss. Meta-analysis of research on the effect of vitamin D supplements on IVF results showed improved clinical pregnancy after IVF when vitamin D supplements were used of at least 1,000-10,000 IU/daily for 30-60 days.
Folic acid: Increased intake of folic acid (800 mg/day) was associated with higher ovarian reserve and also shown to improve ovulatory function and higher live-birth rate after IVF.
For couples pursuing IVF treatment, optimizing egg quality becomes even more critical. Egg quality supplements can provide several advantages in this context:
Increased Egg Yield: Supplements may help stimulate the development of more high-quality eggs, increasing the chances of successful fertilization during IVF.
Enhanced Embryo Quality: Better egg quality often leads to healthier embryos, which can result in a higher likelihood of successful implantation.
Improved Response to Ovarian Stimulation: Supplements can enhance a woman's response to ovarian stimulation medications, increasing the number of eggs available for retrieval during IVF.
Selecting the right egg quality supplements can be challenging, as individual needs vary. It is essential to consult with a fertility specialist and nutritionist before adding any supplements to your regimen. Factors to consider when choosing supplements include your age, specific fertility issues, and any underlying health conditions.
Additionally, it's crucial to ensure the supplements you choose are of high quality, free from contaminants, and manufactured by reputable companies. Look for supplements that have been tested for purity and potency.
Improving egg quality is a key step for individuals or couples looking to enhance their chances of conceiving, especially in the context of IVF or low ovarian reserve. Egg quality supplements can offer a promising avenue for achieving this goal. However, they should be used in consultation with a healthcare professional who can provide personalized guidance and monitor your progress. Book a consultation with a fertility specialist.
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